Effects of endurance training on glucose tolerance and plasma lipid levels in older men and women

JAMA. 1984 Aug 3;252(5):645-9.

Abstract

Eleven healthy men and women (63 +/- 1 years) participated in a 12-month endurance-training program to determine the effects of low-intensity and high-intensity training on glucose tolerance and plasma lipids in older persons. Plasma glucose, insulin, and C-peptide concentrations were measured for three hours after ingestion of 100 g of glucose and the total areas under the respective curves were calculated. Total plasma lipids and lipoprotein concentrations were determined during fasting. Maximal oxygen uptake increased 12% during six months of low-intensity training; a further 18% increase occurred during an additional six months of high-intensity training. Glucose tolerance, which was normal initially, was not significantly changed after training. However, the total area for insulin was 8% lower after low-intensity training, and 23% lower after high-intensity training, compared with before training. C-peptide concentrations were similarly reduced. Plasma lipid and lipoprotein concentrations were unchanged after low-intensity training, but high-intensity training resulted in an increase in high-density lipoprotein cholesterol and a reduction in triglycerides. These results demonstrate that older persons respond to prolonged, high-intensity endurance training with an increase in sensitivity to insulin and a favorable alteration in their plasma lipoprotein-lipid profile.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Blood Glucose / analysis
  • C-Peptide / blood
  • Cholesterol / blood
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Female
  • Glucose Tolerance Test*
  • Humans
  • Insulin / blood
  • Lipids / blood*
  • Lipoproteins, HDL / blood
  • Lipoproteins, LDL / blood
  • Male
  • Middle Aged
  • Oxygen / physiology
  • Physical Education and Training*
  • Respiration

Substances

  • Blood Glucose
  • C-Peptide
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Insulin
  • Lipids
  • Lipoproteins, HDL
  • Lipoproteins, LDL
  • Cholesterol
  • Oxygen