The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: macrophages of endocrine organs

Proc Natl Acad Sci U S A. 1984 Jul;81(13):4174-7. doi: 10.1073/pnas.81.13.4174.


Macrophages of endocrine organs have been identified by immunohistochemical localization of the macrophage-specific antigen F4/80. F4/80+ cells line vascular sinuses and capillaries in anterior and posterior pituitary, adrenal cortex, corpus luteum, parathyroid, pineal gland, and islets of Langerhans. In testis approximately 20% of interstitial cells are F4/80+. F4/80+ cells infiltrate corpus luteum in increased numbers during luteolysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenal Cortex / immunology
  • Animals
  • Antigens, Surface / analysis*
  • Female
  • Immunoassay
  • Islets of Langerhans / immunology
  • Macrophages / immunology*
  • Male
  • Mice
  • Monocytes / immunology*
  • Ovary / immunology
  • Parathyroid Glands / immunology
  • Phagocytosis
  • Pineal Gland / immunology
  • Pituitary Gland / immunology
  • Testis / immunology
  • Thyroid Gland / immunology
  • Tissue Distribution


  • Antigens, Surface