Serum immunoglobulin sedimentation patterns and circulating immune complexes in IgA glomerulonephritis and Schönlein-Henoch nephritis

Acta Med Scand. 1984;215(5):435-41. doi: 10.1111/j.0954-6820.1984.tb17675.x.


Sera from 8 patients with IgA glomerulonephritis and from 6 patients with Schönlein-Henoch nephritis were investigated by the C1q-binding assay (C1q-BA) test and by sucrose gradient centrifugation followed by sensitive solid phase radioimmunoassay determinations of IgA, IgG and IgM in each fraction obtained. Abnormal sedimentation profiles were found in sera from 3 of 8 patients with IgA nephritis and in 3 of 6 patients with Schönlein-Henoch nephritis. The abnormal fraction consisted of low molecular weight IgA in 2 patients, IgG in 1 patient and IgM in 4 patients. The absolute level of polymeric IgA was increased in 3 of 8 patients with IgA nephritis, but the relative distribution was normal. An abnormal sedimentation pattern of immunoglobulins was correlated to a positive C1q-BA test (p less than 0.001).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Antigen-Antibody Complex / analysis*
  • Centrifugation, Density Gradient
  • Child
  • Complement Activation
  • Complement C1
  • Female
  • Glomerulonephritis / immunology*
  • Humans
  • Immunoglobulin A / analysis*
  • Immunoglobulin G / analysis*
  • Immunoglobulin M / analysis*
  • Immunologic Techniques
  • Lupus Erythematosus, Systemic / immunology
  • Male
  • Middle Aged
  • Nephritis / immunology*
  • Radioimmunoassay
  • Syndrome


  • Antigen-Antibody Complex
  • Complement C1
  • Immunoglobulin A
  • Immunoglobulin G
  • Immunoglobulin M