Thrombotic disease in newborn infants

Clin Perinatol. 1984 Jun;11(2):461-88.


Thrombosis in newborn infants is probably more common that at any other period of life. This article highlights the neonate's tendency to develop thrombotic lesions, both in the absence and presence of indwelling catheters. Thrombosis associated with indwelling catheters is discussed in detail. Non-catheter-induced thrombosis is discussed along with its predisposing factors and the major sites of neonatal thrombi and their sequelae. An outline is then offered for a reasonable diagnostic and therapeutic approach.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Blood Vessels / pathology
  • Catheters, Indwelling / adverse effects
  • Coumarins / therapeutic use
  • Heparin / therapeutic use
  • Humans
  • Infant, Newborn
  • Risk
  • Thrombophlebitis / etiology
  • Thrombosis / diagnosis
  • Thrombosis / drug therapy
  • Thrombosis / etiology*
  • Thrombosis / pathology
  • Thrombosis / surgery
  • Umbilical Arteries
  • Umbilical Veins
  • Urokinase-Type Plasminogen Activator / therapeutic use


  • Coumarins
  • Heparin
  • Urokinase-Type Plasminogen Activator