Nucleotide sequence of the lspA gene, the structural gene for lipoprotein signal peptidase of Escherichia coli

FEBS Lett. 1984 Jul 23;173(1):264-8. doi: 10.1016/0014-5793(84)81060-1.


The nucleotide sequence of the lspA gene coding for lipoprotein signal peptidase of Escherichia coli was determined and the amino acid sequence of the peptidase was deduced from it. The molecular mass and amino acid composition of the predicted lipoprotein signal peptidase were consistent with those of the signal peptidase purified from cells harboring the lspA gene-carrying plasmid. The peptidase most probably has no cleavable signal peptide. The lspA gene was preceded by the ileS gene coding for isoleucyl-tRNA synthetase and the tandem termination codons of the ileS gene overlapped with the initiation codon of the lspA gene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • DNA, Bacterial / genetics
  • Endopeptidases / genetics*
  • Endopeptidases / isolation & purification
  • Escherichia coli / genetics*
  • Genes
  • Genes, Bacterial*
  • Membrane Proteins*
  • Molecular Weight
  • Serine Endopeptidases*


  • DNA, Bacterial
  • Membrane Proteins
  • Endopeptidases
  • Serine Endopeptidases
  • type I signal peptidase

Associated data

  • GENBANK/X00776