The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: macrophages of bone and associated connective tissue

J Cell Sci. 1984 Mar:66:189-94. doi: 10.1242/jcs.66.1.189.


The macrophage-specific antigen F4/80 has been localized in adult mouse bone and connective tissue. F4/80 positive cells form the centre of haemopoietic islands, line the periosteal and subendosteal bone surfaces and are a major component of connective tissue and the synovial membrane (presumptive type A cells). F4/80 is absent from fibroblasts, chondrocytes, osteoblasts, osteocytes, osteoclasts and a subpopulation of synovial lining cells (presumptive type B cells).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens / analysis*
  • Bone and Bones / immunology*
  • Connective Tissue / immunology*
  • Immunoenzyme Techniques
  • Macrophages / immunology*
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Osteoclasts / immunology
  • Synovial Membrane / immunology


  • Antigens