Abstract
A membrane glycoprotein isolated from embryonic brain has been shown to be a ligand in the formation of cell-cell bonds. The molecule, called neural cell adhesion molecule (N-CAM), participates in several aspects of neural development, including the formation of plexiform layers, neurite fasciculation and nerve-muscle interactions. Experiments in vivo indicate that N-CAM-mediated adhesion is essential to the orderly assembly of the visual system.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Antigens, Surface / isolation & purification
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Antigens, Surface / physiology*
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Axons / physiology
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Cell Adhesion
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Cell Adhesion Molecules
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Embryo, Mammalian / physiology
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Embryo, Nonmammalian
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Muscles / embryology
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Nervous System / embryology
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Neuromuscular Junction / physiology
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Neurons / physiology*
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Retina / embryology
Substances
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Antigens, Surface
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Cell Adhesion Molecules