Breakdown of the blood-retinal barriers and cystoid macular edema

Surv Ophthalmol. 1984 May;28 Suppl:485-92. doi: 10.1016/0039-6257(84)90230-3.


After reviewing the definition, incidence and main etiologic factors of cystoid macular edema (CME) the authors analyze the structural and physiologic characteristics of the macular area, including the blood-retinal barriers, and the basic concepts of retinal edema. Personal observations on three different groups of diseases associated with CME, retinitis pigmentosa, pars planitis and aphakia, are presented. CME evaluation was made by slit-lamp microscopy, fluorescein angiography and vitreous fluorophotometry. In the situations examined, the main factors involved in CME formation appear to be a marked increase in blood-retinal-barrier barrier permeability and alterations in retinal tissue compliance.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aphakia, Postcataract / complications
  • Capillary Permeability*
  • Child
  • Elasticity
  • Female
  • Fluorescein Angiography
  • Fluorometry
  • Humans
  • Hydrostatic Pressure
  • Macular Edema / diagnosis
  • Macular Edema / etiology
  • Macular Edema / physiopathology*
  • Male
  • Middle Aged
  • Osmotic Pressure
  • Photometry
  • Retina / anatomy & histology
  • Retina / physiopathology
  • Retinal Vessels / physiopathology*
  • Retinitis Pigmentosa / complications
  • Uveitis / complications