Amniotic fluid and midtrimester amniocentesis: a review

Br J Obstet Gynaecol. 1984 Aug;91(8):745-50. doi: 10.1111/j.1471-0528.1984.tb04843.x.


The potential risks of midtrimester amniocentesis resulting from the loss of amniotic fluid are reviewed. Amniotic fluid fulfils important functions in fetal well-being, but its replacement time after amniocentesis is not known. A review of experimental amniocentesis in animals suggests risks to limbs and structural changes in fetal lungs. In humans, orthopaedic abnormalities and respiratory difficulties appear to be a risk of amniocentesis, and studies addressing these risks are also reviewed. Continued investigation of risks from fluid loss at midtrimester amniocentesis is recommended.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Amniocentesis / adverse effects*
  • Amniotic Fluid / physiology*
  • Animals
  • Congenital Abnormalities / etiology
  • Female
  • Gestational Age
  • Humans
  • Infant, Newborn
  • Macaca
  • Mice
  • Pregnancy
  • Pregnancy Trimester, Second
  • Rats
  • Respiratory Distress Syndrome, Newborn / etiology
  • Risk
  • Time Factors
  • Vital Capacity