Hypertension and proteinuria: long-term sequelae of uninephrectomy in humans

Kidney Int. 1984 Jun;25(6):930-6. doi: 10.1038/ki.1984.112.


Renal function and blood pressure were assessed in 52 renal allograft donors 10 years or more following uninephrectomy, and their current function compared to their pre-uninephrectomy function as well as to age- and sex-matched control subjects consisting of inpatient potential renal donors and a normal "outpatient" population. The results show no significant deterioration in renal function as determined by serum creatinine or creatinine clearance, as a function of years post-uninephrectomy or age at the time of donation. A higher incidence of proteinuria and hypertension was found in male donors as compared to their pre-uninephrectomy values and to age- and sex-matched, inpatient and outpatient control subjects. Female donors had increased proteinuria when compared to pre-uninephrectomy and to age-matched, inpatient potential donors. However, the extent of proteinuria and hypertension was not significantly different from outpatient age-matched females with two kidneys. In our population, uninephrectomy is associated with mild proteinuria and hypertension.

MeSH terms

  • Adult
  • Aged
  • Creatinine / blood
  • Female
  • Follow-Up Studies
  • Glomerular Filtration Rate
  • Humans
  • Hypertension, Renal / physiopathology*
  • Kidney Transplantation
  • Male
  • Middle Aged
  • Nephrectomy*
  • Postoperative Complications / physiopathology
  • Proteinuria / physiopathology*
  • Risk
  • Sex Factors
  • Tissue Donors*


  • Creatinine