Resistance to Challenge and Macrophage Activity in Mice Previously Vaccinated With Formalin-Killed Cryptococcus Neoformans

Mycopathologia. 1984 Jun 30;86(3):169-77. doi: 10.1007/BF00441128.

Abstract

Mice were vaccinated with formalin-killed Cryptococcus neoformans either intranasally, intravenously, or intraperitoneally. Resistance to lethal challenge and in vitro phagocytic activity of alveolar and peritoneal macrophages was studied. Increased resistance to lethal challenge was seen following vaccination by each of the three routes but increased phagocytic activity was seen only in alveolar macrophages from mice vaccinated intranasally.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Intranasal
  • Animals
  • Ascitic Fluid
  • Cryptococcosis / immunology*
  • Cryptococcosis / mortality
  • Cryptococcus / immunology*
  • Cryptococcus neoformans / immunology*
  • Fungal Vaccines / administration & dosage
  • Fungal Vaccines / immunology*
  • Immunization
  • Injections, Intraperitoneal
  • Injections, Intravenous
  • Macrophages / immunology*
  • Male
  • Mice
  • Mice, Inbred Strains
  • Phagocytosis*
  • Pulmonary Alveoli / cytology

Substances

  • Fungal Vaccines