Human chromosomal mapping of genes for insulin-like growth factors I and II and epidermal growth factor

Nature. 1984 Aug 30-Sep 5;310(5980):781-4. doi: 10.1038/310781a0.

Abstract

Many of the actions previously attributed to pituitary-derived growth hormone are mediated by polypeptide growth factors. These include the insulin-like growth factors I and II (IGF-I and IGF-II), which are members of the insulin family of proteins. We report here the chromosomal mapping of the human genes for IGF-I and IGF-II. IGF-II maps to the short arm of chromosome 11, which also contains the gene for insulin and the proto-oncogene c-Ha-ras1 (ref. 9). IGF-I maps to chromosome 12, which is evolutionarily related to chromosome 11 and carries the gene for the proto-oncogene c-Ki-ras2 (refs 10,44). We have also localized the human gene for an unrelated polypeptide hormone, epidermal growth factor, to chromosome 4q, in the same region as another specialized growth factor, T-cell growth factor. We speculate that these map assignments reflect the existence of gene families involved in growth control.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Chromosome Mapping
  • Chromosomes, Human, 4-5*
  • Cloning, Molecular
  • Cricetinae
  • Cricetulus
  • Epidermal Growth Factor / genetics*
  • Genes*
  • Humans
  • Hybrid Cells / metabolism
  • Insulin / genetics*
  • Nucleic Acid Hybridization
  • Peptides / genetics*
  • Somatomedins / genetics*

Substances

  • Insulin
  • Peptides
  • Somatomedins
  • Epidermal Growth Factor