Overview of patient compliance with medication dosing: a literature review

Clin Ther. 1984;6(5):592-9.


The literature was reviewed in an effort to relate frequency of dosing and other influences with patient compliance in medication taking. Once-a-day and twice-a-day regimens were associated with significantly better compliance (73% and 70%, respectively) than were three-times-daily (52%) and four-times-daily (42%) regimens. Compliance is not related to income, social class, occupation, or educational background, and it cannot be accurately predicted by physicians. Unintentional errors in taking medication are made by 50% to 90% of patients.

Publication types

  • Review

MeSH terms

  • Adult
  • Child
  • Drug Administration Schedule
  • Drug Therapy*
  • Educational Status
  • Humans
  • Income
  • Occupations
  • Patient Compliance*
  • Self Administration
  • Social Class
  • Time Factors