The proteolytic activity of human prostate-specific antigen

Biochem Biophys Res Commun. 1984 Sep 17;123(2):482-8. doi: 10.1016/0006-291x(84)90256-0.


Human prostate-specific antigen has been found to exhibit a mild activity of protease at neutral pH. This finding is based on two observations: a proteolytic activity was always associated with the antigen fractions during purification, and the proteolytic activity and the antigen were precipitated with specific antibody to the antigen. In comparison with physico-chemical and catalytic properties of known proteases, human prostate-specific antigen is a distinct neutral protease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigens / metabolism*
  • Cattle
  • Goats
  • Humans
  • Hydrogen-Ion Concentration
  • Male
  • Mice
  • Peptide Hydrolases / metabolism*
  • Prostate / immunology*
  • Prostate / metabolism
  • Substrate Specificity
  • Swine


  • Antigens
  • Peptide Hydrolases