Three-day therapy with cephalexin for lower urinary tract infections in children

Scand J Infect Dis. 1984;16(3):305-7. doi: 10.3109/00365548409070405.

Abstract

In a prospective study of children with an acute infection of the lower urinary tract, the effectiveness of a 3-day course of cephalexin, 25-50 mg/kg body weight and day was compared with that of a 10-day course of nitrofurantoin, 3-4 mg/kg/day. 19 children were allotted to treatment with cephalexin and 24 were treated with nitrofurantoin. The immediate cure rates were 90% and 96%, respectively. Two relapses were noted in the cephalexin group and 1 in the nitrofurantoin group. During a mean follow-up period of 7-8 months 2 of the cephalexin treated patients and 4 patients treated with nitrofurantoin had a reinfection. No side effects were noted in either of the treatment groups. The results suggest that treatment with cephalexin for 3 days is a reasonable alternative in children with an acute lower urinary tract infection when commonly used medications for one reason or another are less well tolerated.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Bacteriuria / drug therapy*
  • Cephalexin / therapeutic use*
  • Child
  • Escherichia coli Infections / drug therapy
  • Female
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Nitrofurantoin / therapeutic use*
  • Proteus Infections / drug therapy
  • Recurrence

Substances

  • Nitrofurantoin
  • Cephalexin