Role of DNA replication in the repression of silent mating type loci in yeast

Nature. 1984 Nov 15-21;312(5991):247-51. doi: 10.1038/312247a0.


A putative origin of DNA replication is associated with the DNA sequences necessary for the repression of silent mating type loci in yeast. These sequences lie about a kilobase away from the affected promoters, so the repression must act at a distance. We show here that DNA replication is required for the onset of repression.

MeSH terms

  • Animals
  • DNA Replication*
  • Fungal Proteins / genetics*
  • Gene Expression Regulation
  • Mating Factor
  • Peptides / genetics*
  • Pheromones / genetics
  • Recombination, Genetic
  • Saccharomyces cerevisiae / genetics*


  • Fungal Proteins
  • Peptides
  • Pheromones
  • Mating Factor