Alcohol preference and voluntary alcohol intakes of inbred rat strains and the National Institutes of Health heterogeneous stock of rats

Alcohol Clin Exp Res. Sep-Oct 1984;8(5):485-6. doi: 10.1111/j.1530-0277.1984.tb05708.x.

Abstract

The alcohol preference ratios and the daily free-choice ethanol intakes (10% ethanol versus water) of the newly constituted National Institutes of Health (NIH) heterogeneous stock (N/Nih) rats, and of the eight inbred strains from which N/Nih derived, were measured. Among the eight inbred strains, ACI/N, WKY/N, F344/N, BUF/N, BN/Ssn, WN/N, M520/N, and MR/N, the ACI exhibited the lowest preference and intakes and the MR and the M520 the highest. The mean values for the N/Nih animals were intermediate among those of the inbred strains. The range of intake for the N/Nih rats was 0.06-9.5 g/kg of body weight/day, indicating that they should serve as an appropriate foundation in selection studies for alcohol-drinking preference.

Publication types

  • Comparative Study

MeSH terms

  • Alcohol Drinking*
  • Alcoholism / genetics*
  • Animals
  • Crosses, Genetic
  • Disease Models, Animal*
  • Genotype
  • Humans
  • Rats
  • Rats, Inbred Strains