Combined therapy with captopril and potassium supplementation. A potential for hyperkalemia

Arch Intern Med. 1984 Dec;144(12):2371-2.


Captopril (Capoten), an angiotensin-converting enzyme inhibitor, is being used increasingly in the treatment of both hypertension and congestive heart failure. Many of the patients with these disease states have treatment regimens including potassium-sparing diuretics or potassium supplements. In monitoring of five such patients, a significant increase in serum potassium level (3.88 +/- 0.41 to 4.84 +/- 0.45 mEq/L) was noted once captopril was added to their therapy. Laboratory-diagnosed hyperkalemia occurred in three of these patients. Serum potassium levels remained elevated until potassium supplementation or captopril therapy was reduced or discontinued. The combination of captopril and potassium supplements or potassium-sparing diuretics represents a potentially important drug interaction. Patients should be closely monitored for possible hyperkalemia when using these drug combinations.

MeSH terms

  • Aged
  • Captopril / adverse effects*
  • Captopril / pharmacology
  • Drug Interactions
  • Drug Therapy, Combination
  • Female
  • Heart Failure / drug therapy
  • Humans
  • Hyperkalemia / chemically induced*
  • Hypertension / drug therapy
  • Male
  • Middle Aged
  • Potassium / adverse effects*
  • Potassium / blood
  • Potassium / pharmacology
  • Proline / analogs & derivatives*


  • Proline
  • Captopril
  • Potassium