Phenotypic and genetic analysis of the silver-Russell syndrome

Clin Genet. 1978 Mar;13(3):278-88. doi: 10.1111/j.1399-0004.1978.tb01182.x.


A family is reported in which two half-siblings present clinical findings suggestive of the Silver-Russell syndrome (SRS). The available published literature on SRS is reviewed and the variable expression of the syndrome demonstrated. A review of published pedigrees of the syndrome suggests that in a small percentage of cases, SRS has a genetic etiology.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Child, Preschool
  • Dermatoglyphics
  • Dwarfism / genetics*
  • Female
  • Humans
  • Hypertrophy
  • Male
  • Pedigree
  • Phenotype
  • Puberty, Precocious / genetics*
  • Syndrome