Abstract
Fluoridated drinking water (30 mg and 100 mg F per liter) was used to induce rachitic changes in rats fed a vitamin D free diet containing calcium and phosphorus in a ratio of 1 : 1. Supplements of vitamin D3 (70 IU of cholecalciferol per week) completely prevented the rachitogenic effects of fluoride. This protective effect occurred despite evidence that vitamin D enhanced the intestinal absorption of fluoride.
MeSH terms
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Animals
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Bone Diseases / chemically induced
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Bone Diseases / prevention & control
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Calcium Phosphates / metabolism
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Calcium, Dietary
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Fluoridation
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Fluorides / adverse effects*
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Fluorides / therapeutic use
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Intestinal Absorption / drug effects
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Magnesium / metabolism
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Male
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Models, Biological
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Osteoporosis / drug therapy
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Phosphorus / metabolism
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Rats
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Rickets / chemically induced
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Rickets / prevention & control
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Vitamin D / therapeutic use*
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Vitamin D Deficiency / pathology
Substances
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Calcium Phosphates
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Calcium, Dietary
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Vitamin D
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Phosphorus
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Magnesium
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Fluorides