A double-blind controlled clinical trial of mastic and placebo in the treatment of duodenal ulcer

Clin Exp Pharmacol Physiol. 1984 Sep-Oct;11(5):541-4. doi: 10.1111/j.1440-1681.1984.tb00864.x.


A double-blind clinical trial was carried out on thirty-eight patients with symptomatic and endoscopically proven duodenal ulcer to compare the therapeutic responses to mastic (1 g daily, twenty patients) and placebo (lactose, 1 g daily, eighteen patients) given orally over a period of 2 weeks. Symptomatic relief was obtained in sixteen (80%) patients on mastic and in nine (50%) patients on placebo, while endoscopically proven healing occurred in fourteen (70%) patients on mastic and four (22%) patients on placebo. The differences between treatments were highly significant (P less than 0.01). Mastic was well tolerated and did not produce side effects. It is concluded that mastic has an ulcer healing effect, but further studies are needed to establish its role in treating peptic ulcer.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Clinical Trials as Topic
  • Double-Blind Method
  • Duodenal Ulcer / drug therapy*
  • Female
  • Humans
  • Male
  • Mastic Resin
  • Middle Aged
  • Plant Extracts / therapeutic use*
  • Plants, Medicinal*
  • Random Allocation
  • Resins, Plant / therapeutic use*


  • Mastic Resin
  • Plant Extracts
  • Resins, Plant