[Treatment of essential headache in developmental age with L-5-HTP (cross over double-blind study versus placebo)]

Pediatr Med Chir. Mar-Apr 1984;6(2):241-5.
[Article in Italian]


Thirty patients (mean age: 10.38 years) affected by primary headache were selected for a double-blind cross-over clinical trial. The patients were randomized into 2 homogeneous groups of 15 and treated for 12 weeks with L-5-HTP (100 mg/day) and placebo as per the following design: placebo - L-5-HTP (group A) and L-5-HTP - placebo (group B). Evaluation was carried out every 3 weeks by the Migraine Index supplying a general assessment of the attacks, i.e. severity, duration and frequency. The decrease in mean score values was directly proportional to L-5-HTP treatment, and statistical significance (Wilcoxon's test) was observed only for L-5-HTP in both groups, from 0.05 to 0.01. Improvement, as evaluated by CGI on percentage distribution of the patients, was homogeneous in both groups.

Publication types

  • Clinical Trial
  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • 5-Hydroxytryptophan / therapeutic use*
  • Adolescent
  • Child
  • Clinical Trials as Topic
  • Double-Blind Method
  • Female
  • Headache / drug therapy*
  • Humans
  • Male
  • Placebos


  • Placebos
  • 5-Hydroxytryptophan