Platelet-vessel wall interactions: implication of 5-hydroxytryptamine. A review

Agents Actions. 1984 Dec;15(5-6):612-26. doi: 10.1007/BF01966783.

Abstract

The evidence for an impact of platelet-derived 5-hydroxytryptamine (5-HT) on local tissue perfusion is reviewed. By interacting with 5-HT2 serotonergic receptors, 5-HT, directly or through amplification, activates platelets, endothelial and vascular smooth muscle cells producing platelet aggregation, vascular permeability increase and large vessel constriction. Pharmacodissection in experimental animals with selective serotonergic 5-HT2 receptor antagonists, e.g. ketanserin, shows that 5-HT largely contributes to the platelet-mediated increase in vascular permeability, to platelet-vessel wall interaction during hemostasis, to cardiopulmonary dysfunction provoked by thromboembolism and to the platelet-mediated inhibition of peripheral collateral circulation. Clinical results obtained with ketanserin further substantiate an involvement of platelet-derived 5-HT in the pathogenesis of impaired tissue perfusion in some cardiovascular conditions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Blood Platelets / drug effects
  • Blood Platelets / physiology*
  • Blood Vessels / drug effects
  • Blood Vessels / physiology*
  • Capillary Permeability
  • Endothelium / drug effects
  • Endothelium / physiology
  • Humans
  • In Vitro Techniques
  • Ketanserin
  • Muscle, Smooth, Vascular / drug effects
  • Muscle, Smooth, Vascular / physiology
  • Piperidines / therapeutic use
  • Receptors, Serotonin / drug effects
  • Serotonin / pharmacology
  • Serotonin / physiology*
  • Vasoconstriction

Substances

  • Piperidines
  • Receptors, Serotonin
  • Serotonin
  • Ketanserin