Sustained insulin-induced remissions of juvenile diabetes by means of an external artificial pancreas

Diabetologia. 1978 Apr;14(4):223-7. doi: 10.1007/BF01219420.


Remission of diabetes was attempted in 12 recent acute onset ketosis-prone juvenile diabetes after short term (5 +/- 1 days) but excellent blood glucose control by the external artificial beta-cell. The comparison group comrised patients undergoing traditional treatment (n = 28). Nine (75%) persistent (over 3-14 months of duration) although partial (oral drugs required) remissions were obtained in the former group as compared to 3 (11%) in the latter group (p less than 0.05). Cases which showed remissions after insulin infusion had a plasma insulin response to IV glucagon still present before insulin infusion, and a daily urinary C-peptide excretion significantly enhanced after (p less than 0.01). Urinary C-peptide/blood glucose remained improved during the remission period. Thus, early effective treatment by means of the artificial pancreas may break the vicious circle hyperglycaemia-insulin depletion-hyperglycaemia and lead to frequent and sustained remissions of juvenile diabetes.

MeSH terms

  • Acute Disease
  • Adolescent
  • Adult
  • C-Peptide / blood
  • Diabetes Mellitus, Type 1 / blood
  • Diabetes Mellitus, Type 1 / drug therapy*
  • Humans
  • Insulin / blood
  • Insulin / therapeutic use*
  • Monitoring, Physiologic / methods
  • Pancreas*
  • Remission, Spontaneous
  • Time Factors


  • C-Peptide
  • Insulin