[Pharmacological Characteristics of a New Phenyl Analog of piracetam--4-phenylpiracetam]

Biull Eksp Biol Med. 1983 Apr;95(4):50-3.
[Article in Russian]

Abstract

The central neurotropic effects of 4-phenylpyracetam, a new phenyl analog of pyracetam, were studied and compared with the effects of pyracetam, morpholene and 4-phenylpyrrolidone. 4-Phenylpyracetam was found to activate the operant behavior more powerfully, to remove psychodepressant effects of diazepam, to inhibit post-rotational nystagmus, and to prevent the development of retrograde amnesia. Unlike pyracetam, 4-phenylpyracetam exhibits a specific anticonvulsant action. When given in high doses, the compound under study produces psychodepressant effects.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Animals
  • Anticonvulsants / pharmacology
  • Conditioning, Operant / drug effects
  • Dose-Response Relationship, Drug
  • Drug Evaluation, Preclinical
  • Epilepsies, Partial / drug therapy
  • Guinea Pigs
  • Mice
  • Morpholines / pharmacology
  • Nystagmus, Physiologic / drug effects
  • Piracetam / analogs & derivatives
  • Piracetam / pharmacology*
  • Piracetam / therapeutic use
  • Piracetam / toxicity
  • Pyrrolidinones / pharmacology*
  • Rats

Substances

  • Anticonvulsants
  • Morpholines
  • Pyrrolidinones
  • morfolep
  • 4-phenylpiracetam
  • Piracetam