Abstract
The central neurotropic effects of 4-phenylpyracetam, a new phenyl analog of pyracetam, were studied and compared with the effects of pyracetam, morpholene and 4-phenylpyrrolidone. 4-Phenylpyracetam was found to activate the operant behavior more powerfully, to remove psychodepressant effects of diazepam, to inhibit post-rotational nystagmus, and to prevent the development of retrograde amnesia. Unlike pyracetam, 4-phenylpyracetam exhibits a specific anticonvulsant action. When given in high doses, the compound under study produces psychodepressant effects.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Animals
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Anticonvulsants / pharmacology
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Conditioning, Operant / drug effects
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Dose-Response Relationship, Drug
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Drug Evaluation, Preclinical
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Epilepsies, Partial / drug therapy
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Guinea Pigs
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Mice
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Morpholines / pharmacology
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Nystagmus, Physiologic / drug effects
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Piracetam / analogs & derivatives
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Piracetam / pharmacology*
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Piracetam / therapeutic use
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Piracetam / toxicity
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Pyrrolidinones / pharmacology*
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Rats
Substances
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Anticonvulsants
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Morpholines
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Pyrrolidinones
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morfolep
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4-phenylpiracetam
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Piracetam