Hypoxic-ischemic encephalopathy in the newborn

Arch Neurol. 1983 May;40(5):261-6. doi: 10.1001/archneur.1983.04050050029002.

Abstract

Many term newborns suffer some degree of perinatal asphyxia, but few become permanently brain damaged as a consequence, The newborns at risk for major neurologic handicaps have evidence of derangement in many organs, depressed cerebral function at birth that continues for days or weeks, and in many cases, convulsions soon after birth. The pathophysiologic mechanism of brain damage in hypoxic-ischemic encephalopathy remains contested, and no specific therapy is clearly beneficial. The immediate treatment of the asphyxiated term newborn requires attention to the derangements in multiple organ systems and the use of anticonvulsants when indicated.

Publication types

  • Review

MeSH terms

  • Animals
  • Asphyxia Neonatorum / diagnosis
  • Asphyxia Neonatorum / drug therapy
  • Asphyxia Neonatorum / metabolism
  • Asphyxia Neonatorum / physiopathology*
  • Brain Ischemia / diagnosis
  • Brain Ischemia / drug therapy
  • Brain Ischemia / metabolism
  • Brain Ischemia / physiopathology*
  • Cerebrovascular Circulation
  • Disease Models, Animal
  • Energy Metabolism
  • Glucose / metabolism
  • Haplorhini
  • Humans
  • Hypoxia, Brain / diagnosis
  • Hypoxia, Brain / drug therapy
  • Hypoxia, Brain / metabolism
  • Hypoxia, Brain / physiopathology*
  • Infant, Newborn
  • Infant, Newborn, Diseases / diagnosis
  • Infant, Newborn, Diseases / drug therapy
  • Infant, Newborn, Diseases / metabolism
  • Infant, Newborn, Diseases / physiopathology
  • Lactates / metabolism

Substances

  • Lactates
  • Glucose