In vitro study of in line filtration of medications commonly administered to pediatric cancer patients

JPEN J Parenter Enteral Nutr. 1983 Mar-Apr;7(2):156-8. doi: 10.1177/0148607183007002156.

Abstract

Intravenous administration of drugs commonly used in patients with acute nonlymphocytic leukemia was simulated using a .22 micrometers air-eliminating filter. Drug concentrations were measured pre- and postfiltration using standard pediatric drug doses and concentrations. The percentage of administered dose recovered in the postfilter sample for chemotherapy drugs was adriamycin, 92%; dactinomycin, 87%; cytarabine, 96%; and vincristine, 90%. For antibiotics, the per cent recovery was carbenicillin, 90%; cephalothin, 96%; and gentamicin, 38%. Gentamicin, and perhaps other drugs evaluated, should not be administered through a filter of the type used in this study.

MeSH terms

  • Anti-Bacterial Agents / administration & dosage*
  • Antineoplastic Agents / administration & dosage*
  • Child
  • Filtration
  • Humans
  • Infusions, Parenteral / methods
  • Neoplasms / drug therapy
  • Parenteral Nutrition, Total

Substances

  • Anti-Bacterial Agents
  • Antineoplastic Agents