Multiple myeloma presenting as dense deposit disease. Light chain nephropathy

H Knobler; J Kopolovic; Y Kleinman; D Rubinger; J Silver; M M Friedlaender; M M Popovtzer

doi:10.1159/000182980

Multiple myeloma presenting as dense deposit disease. Light chain nephropathy

Nephron. 1983;34(1):58-63. doi: 10.1159/000182980.

Authors

H Knobler, J Kopolovic, Y Kleinman, D Rubinger, J Silver, M M Friedlaender, M M Popovtzer

PMID: 6406920
DOI: 10.1159/000182980

Abstract

A 45-year-old male was admitted to the hospital because of polyuria and polydipsia. After admission, proteinuria and hematuria were found. The kidney function deteriorated and necessitated the initiation of chronic hemodialysis. Examination of the bone marrow revealed multiple myeloma and kappa light chains were found in the urine. The kidney biopsy showed membranoproliferative glomerulonephritis with dense deposits in the glomerular basement membrane.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Basement Membrane / pathology
Biopsy
Glomerulonephritis / etiology
Glomerulonephritis / immunology*
Humans
Immunoglobulin Light Chains / immunology*
Immunoglobulin kappa-Chains / immunology*
Kidney Glomerulus / pathology
Male
Microscopy, Electron
Middle Aged
Multiple Myeloma / complications
Multiple Myeloma / diagnosis*

Substances

Immunoglobulin Light Chains
Immunoglobulin kappa-Chains