Candida Infections in Surgical Patients

Ann Surg. 1983 Jul;198(1):42-7. doi: 10.1097/00000658-198307000-00008.

Abstract

Serious Candida infections were seen in 55 surgical patients from January 1977 through December 1980. Most of the patients had compromising underlying conditions and many were elderly. Broad-spectrum antibiotics and total parenteral nutrition (TPN) appeared to predispose patients to Candida infections. Mortality rate from Candida was 38%. A high percentage of patients with positive blood or bile cultures died as a result of Candida infection. Therapy with intravenous amphotericin B was highly effective if given in adequate dosage. No patient receiving more than 200 mg of amphotericin B died, but the mortality rate was 56% in those receiving lower doses.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Amphotericin B / administration & dosage
  • Anti-Bacterial Agents / adverse effects
  • Bile / microbiology
  • Candida / isolation & purification
  • Candida albicans / isolation & purification
  • Candidiasis / drug therapy
  • Candidiasis / etiology*
  • Candidiasis / mortality
  • Child
  • Cross Infection*
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Male
  • Middle Aged
  • Parenteral Nutrition, Total / adverse effects
  • Postoperative Complications
  • Risk
  • Surgical Procedures, Operative*
  • Time Factors

Substances

  • Anti-Bacterial Agents
  • Amphotericin B