Modes of action of lipid-lowering diets in man: studies of apolipoprotein B kinetics in relation to fat consumption and dietary fatty acid composition

Eur J Clin Invest. 1983 Feb;13(1):79-85. doi: 10.1111/j.1365-2362.1983.tb00068.x.


The mechanisms by which dietary fat influences fasting plasma lipid concentrations have been investigated in hyperlipidaemic subjects. The synthetic and fractional catabolic (FCR) rates of the apoprotein B (apo B) of very-low density (VLDL) and low-density (LDL) lipoproteins were measured using radioiodinated autologous lipoproteins. Reductions of LDL concentration in eight subjects during low-fat (25% of energy) diets were largely explained by diminished synthesis (-20%, P less than 0.02), and possibly also by an increased FCR (+15%, P = 0.05) of LDL, compared with observations made during a high-fat (45% of energy) diet of similar fatty acid composition. VLDL apo B synthesis and FCR were not significantly altered. When a diet rich in polyunsaturated fatty acids was exchanged for one high in saturated fatty acids (fat providing 45% of energy on both occasions) in four subjects, the synthetic rates of both VLDL apo B (-31%, P less than 0.02) and LDL apo B (-23%, P less than 0.10) were reduced while their FCRs were unchanged.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Apolipoproteins / metabolism*
  • Apolipoproteins B
  • Cholesterol / blood
  • Dietary Fats / administration & dosage*
  • Fatty Acids, Nonesterified / administration & dosage*
  • Fatty Acids, Nonesterified / analysis
  • Female
  • Humans
  • Hypercholesterolemia / diet therapy
  • Hyperlipidemias / diet therapy*
  • Hyperlipidemias / metabolism
  • Hyperlipoproteinemias / diet therapy
  • Lipoproteins, HDL / blood
  • Lipoproteins, LDL / blood
  • Lipoproteins, VLDL / blood
  • Male
  • Middle Aged
  • Triglycerides / blood


  • Apolipoproteins
  • Apolipoproteins B
  • Dietary Fats
  • Fatty Acids, Nonesterified
  • Lipoproteins, HDL
  • Lipoproteins, LDL
  • Lipoproteins, VLDL
  • Triglycerides
  • Cholesterol