Abstract
The sequencing of eleven cloned Drosophila melanogaster alcohol dehydrogenase (Adh) genes from five natural populations has revealed a large number of previously hidden polymorphisms. Only one of the 43 polymorphisms results in an amino acid change, the one responsible for the two electrophoretic variants (fast, Adh-f, and slow, Adh-s) found in nearly all natural populations. The implication is that most amino acid changes in Adh would be selectively deleterious.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alcohol Dehydrogenase
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Alcohol Oxidoreductases / genetics*
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Animals
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Base Sequence
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Drosophila melanogaster / enzymology
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Drosophila melanogaster / genetics
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Gene Frequency
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Polymorphism, Genetic*
Substances
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Alcohol Oxidoreductases
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Alcohol Dehydrogenase
Associated data
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GENBANK/K00651
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GENBANK/M17827
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GENBANK/M17828
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GENBANK/M17829
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GENBANK/M17830
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GENBANK/M17831
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GENBANK/M17832
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GENBANK/M17833
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GENBANK/M17834
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GENBANK/M17835
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GENBANK/M17836
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GENBANK/M17837
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GENBANK/M19547