Nucleotide polymorphism at the alcohol dehydrogenase locus of Drosophila melanogaster

Nature. 1983 Aug 4-10;304(5925):412-7. doi: 10.1038/304412a0.


The sequencing of eleven cloned Drosophila melanogaster alcohol dehydrogenase (Adh) genes from five natural populations has revealed a large number of previously hidden polymorphisms. Only one of the 43 polymorphisms results in an amino acid change, the one responsible for the two electrophoretic variants (fast, Adh-f, and slow, Adh-s) found in nearly all natural populations. The implication is that most amino acid changes in Adh would be selectively deleterious.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alcohol Dehydrogenase
  • Alcohol Oxidoreductases / genetics*
  • Animals
  • Base Sequence
  • Drosophila melanogaster / enzymology
  • Drosophila melanogaster / genetics
  • Gene Frequency
  • Polymorphism, Genetic*


  • Alcohol Oxidoreductases
  • Alcohol Dehydrogenase

Associated data

  • GENBANK/K00651
  • GENBANK/M17827
  • GENBANK/M17828
  • GENBANK/M17829
  • GENBANK/M17830
  • GENBANK/M17831
  • GENBANK/M17832
  • GENBANK/M17833
  • GENBANK/M17834
  • GENBANK/M17835
  • GENBANK/M17836
  • GENBANK/M17837
  • GENBANK/M19547