A New Site for Islet Transplantation--A Peritoneal-Omental Pouch

Transplantation. 1983 Aug;36(2):181-2. doi: 10.1097/00007890-198308000-00014.

Abstract

A new site for islet transplantation is described. A peritoneal-omental pouch was constructed in diabetic rats by encasing the omentum in a pouch formed from a strip of parietal peritoneum obtained from the recipient. Isografts of rat islets placed in the pouch maintained normoglycemia in the recipients and removal of the pouch resulted in a rapid return to a diabetic state. This site may be applicable to the transplantation of islets in human diabetes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Diabetes Mellitus, Experimental / therapy
  • Islets of Langerhans Transplantation*
  • Male
  • Omentum / transplantation*
  • Peritoneum / transplantation*
  • Rats
  • Rats, Inbred Strains
  • Transplantation, Isogeneic / methods*