Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets

Biochem Biophys Res Commun. 1983 Jul 29;114(2):743-9. doi: 10.1016/0006-291x(83)90843-4.

Abstract

Metapyrone and eicosatetraynoic acid but not indomethacin are effective inhibitors of the secretory response of isolated rat pancreatic islets to arginine and glucose. Epoxyeicosatrienoic acids, products of the cytochrome P-450-NADPH dependent arachidonic acid epoxygenase activity, are potent and selective mediators for the in vitro release of either insulin or glucagon from preparations of isolated rat pancreatic islets.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Arachidonic Acid
  • Arachidonic Acids / metabolism
  • Arachidonic Acids / pharmacology*
  • Arginine / pharmacology
  • Glucagon / metabolism*
  • Glucose / pharmacology
  • Insulin / metabolism*
  • Insulin Secretion
  • Islets of Langerhans / drug effects
  • Islets of Langerhans / metabolism*
  • Kinetics
  • Male
  • Rats
  • Rats, Inbred Strains
  • Structure-Activity Relationship

Substances

  • Arachidonic Acids
  • Insulin
  • Arachidonic Acid
  • Glucagon
  • Arginine
  • Glucose