Strain variation in interferon gamma production of BCG-sensitized mice challenged with PPD. I. CBA/Ca mice are low producers in vivo, but high producers in vitro

Cell Immunol. 1983 Sep;80(2):329-34. doi: 10.1016/0008-8749(83)90121-1.


Three different mouse strains--BALB/c, C57BL/6J, and CBA/Ca--were compared for their production of viral interferon upon Newcastle disease virus (NDV) inoculation and of interferon gamma upon antigenic stimulation with PPD following BCG sensitization. BALB/c mice were found to be low producers for NDV-induced IFN-alpha, beta as well as for in vivo (serum) and in vitro (spleen cell culture) induced IFN-gamma. C57BL/6 mice were high producers under the three conditions tested and CBA/Ca mice, finally, were high IFN-alpha, beta and in vitro IFN-gamma producers, but low in vivo IFN-gamma producers. Development of splenomegaly following BCG inoculation was not directly related to IFN-gamma responsiveness.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • In Vitro Techniques
  • Interferon-gamma / genetics*
  • Lymphocytes / immunology*
  • Male
  • Mice
  • Mice, Inbred BALB C / immunology
  • Mice, Inbred C57BL / immunology
  • Mice, Inbred CBA / immunology
  • Mice, Inbred Strains / immunology*
  • Mycobacterium bovis / immunology*
  • Newcastle disease virus / immunology
  • Organ Size
  • Species Specificity
  • Spleen / immunology
  • Splenomegaly / immunology
  • Tuberculin / immunology*


  • Tuberculin
  • Interferon-gamma