Experimental models of atherosclerosis regression

Atherosclerosis. 1983 Aug;48(2):105-18. doi: 10.1016/0021-9150(83)90097-7.


Regression of atherosclerosis has been demonstrated in several species of animals, including rabbits, chickens, rats, dogs, pigeons, pigs, and nonhuman primates. Regression has been associated with withdrawal of cholesterol from the diet or with the ingestion of cholestyramine, alfalfa meal, or alfalfa saponins in monkeys fed high-cholesterol diets. Although regression of atherosclerosis has been documented by sequential contrast arteriography in humans, the correspondence of regression in animals and in humans needs to be established.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Arteriosclerosis / pathology*
  • Arteriosclerosis / therapy
  • Cholesterol, Dietary / administration & dosage
  • Cholestyramine Resin / administration & dosage
  • Coronary Disease / pathology
  • Coronary Disease / therapy
  • Disease Models, Animal
  • Haplorhini
  • Medicago sativa
  • Rabbits
  • Saponins / administration & dosage
  • Time Factors


  • Cholesterol, Dietary
  • Saponins
  • Cholestyramine Resin