Sequential determination of CRP, alpha 1-antitrypsin and haptoglobin in neonatal septicaemia

Acta Paediatr Scand. 1983 Sep;72(5):679-83. doi: 10.1111/j.1651-2227.1983.tb09793.x.


In 312 preterm and term newborn infants serum concentrations of C-reactive protein (CRP), haptoglobin and alpha 1-antitrypsin were measured during several days by radial immunodiffusion. In addition white blood cell count and the ratio of band to total neutrophils (B/N-ratio) were determined. In 12 infants with proven sepsis CRP was found elevated above the upper limit of the normal range (20 mg/l). Successful therapy was followed by a decrease of CRP concentration. In infants with suspected infection high CRP values were found in most cases. In contrast, haptoglobin and alpha 1-antitrypsin concentrations differed not significantly between the group of infants without infection, with proven and with suspected infection. White blood cell count and B/N-ratio also were not appropriate for the early identification of bacterial infection in the newborn period.

MeSH terms

  • C-Reactive Protein / analysis*
  • Haptoglobins / analysis*
  • Humans
  • Immunodiffusion
  • Infant, Newborn
  • Infant, Premature, Diseases / blood
  • Leukocyte Count
  • Meningitis / blood*
  • Prospective Studies
  • Sepsis / blood*
  • alpha 1-Antitrypsin / analysis*


  • Haptoglobins
  • alpha 1-Antitrypsin
  • C-Reactive Protein