Biochemical, physiological and pathophysiological aspects of intestinal diamine oxidase

Acta Physiol Pol. 1983 Jan-Feb;34(1):139-54.

Abstract

Studies were performed on the distribution and properties of intestinal diamine oxidase (DAO) previously called histaminase. DAO activity is high in the gastrointestinal tract of all investigated species. The highest values are in the aboral part of the small intestine: where DAO is localized in the mucosa, predominantly in the top villus region. A high reaction velocity of human intestinal DAO is observed with putrescine, methylhistamine and histamine. H2 receptor antagonists and an agonist (impromidine) inhibit intestinal DAO. The physiological and pathophysiological significance of intestinal DAO in the regulation of histamine and putrescine levels is described, as is the possibility that DAO may act as a growth retardant.

Publication types

  • Comparative Study

MeSH terms

  • Amine Oxidase (Copper-Containing) / deficiency
  • Amine Oxidase (Copper-Containing) / physiology*
  • Animals
  • Chickens
  • Dogs
  • Female
  • Growth Inhibitors
  • Guinea Pigs
  • Histamine / metabolism
  • Humans
  • Intestinal Neoplasms / etiology
  • Intestinal Neoplasms / prevention & control
  • Intestines / enzymology*
  • Methylhistamines / metabolism
  • Mice
  • Models, Biological
  • Putrescine / metabolism
  • Rabbits
  • Rats
  • Species Specificity
  • Swine

Substances

  • Growth Inhibitors
  • Methylhistamines
  • Histamine
  • Amine Oxidase (Copper-Containing)
  • Putrescine