[18F]fluorodeoxyglucose positron emission tomography in refractory complex partial seizures

Ann Neurol. 1983 Oct;14(4):429-37. doi: 10.1002/ana.410140406.


Positron emission tomography with simultaneous electroencephalographic monitoring was performed with [18F]fluorodeoxyglucose in 20 patients with complex partial seizures who had normal computed tomographic scans. Seven patients had only unilateral epileptiform discharges on the electroencephalogram, 3 had predominantly unilateral discharges, and 10 had nonlocalized epileptiform abnormalities. Positron emission tomography showed a hypometabolic lesion in 16 of the 20 patients. Pathological changes in the hypometabolic region were found in postoperative specimens in 4 of 5 patients studied. Positron emission tomography was unaffected by the seizure frequency, state of alertness, or number of spike discharges during the scan. There was a tendency for patients to have higher overall metabolic rates when taking less medication. Seizures occurring during [18F]fluorodeoxyglucose uptake in 3 patients produced a hypermetabolic area at the interictal hypometabolic focus. Positron emission tomography sometimes showed more widespread hypometabolism than suspected on the basis of the scalp-recorded electroencephalogram. The frontal lobe showed a greater degree of hypometabolism than the temporal lobe in 3 patients. Focal lesions may be identified by positron emission tomography even if the electroencephalographic abnormality is not well localized.

MeSH terms

  • Adult
  • Blood Glucose / metabolism*
  • Brain / metabolism
  • Deoxyglucose / analogs & derivatives
  • Dominance, Cerebral / physiology
  • Electroencephalography
  • Energy Metabolism
  • Epilepsies, Partial / diagnostic imaging
  • Epilepsy, Temporal Lobe / blood
  • Epilepsy, Temporal Lobe / diagnostic imaging*
  • Evoked Potentials
  • Fluorodeoxyglucose F18
  • Humans
  • Tomography, Emission-Computed / methods*


  • Blood Glucose
  • Fluorodeoxyglucose F18
  • Deoxyglucose