Diabetes mellitus, glucose tolerance and insulin response to glucose in patients with primary hyperparathyroidism before and after parathyroidectomy

Eur J Clin Invest. 1983 Oct;13(5):373-7. doi: 10.1111/j.1365-2362.1983.tb00116.x.


In a retrospectively analyzed series of 441 patients operated for primary hyperparathyroidism (HPT), the prevalence of diabetes mellitus was 8.2%, which was three times higher than in the unselected age-matched population. Following parathyroid surgery, the need for antidiabetic treatment was unchanged. The insulin response to an intravenous glucose load was enhanced preoperatively [95 mU/1 +/- 41 (SD)] in twenty-six prospectively studied patients compared to postoperative (65 +/- 41 mU/1) investigations (P less than 0.01). This response was inversely correlated (r = 2, P less than 0.01) to the serum phosphate concentrations but not related to calcium or parathyroid hormone levels. Postoperatively, most HPT patients experienced a deterioration of their glucose tolerance (t 1/2 for i.v. glucose 54 +/- 12 and 64 +/- 21 min, respectively, P less than 0.05), and one-third of them had pathological values at follow-up. Despite this, neither the fasting blood glucose levels nor the values for haemoglobin A1c were significantly affected.

MeSH terms

  • Adult
  • Aged
  • Blood Glucose / metabolism*
  • Diabetes Complications*
  • Diabetes Mellitus / therapy
  • Female
  • Glucose
  • Glucose Tolerance Test
  • Humans
  • Hyperparathyroidism / complications
  • Hyperparathyroidism / surgery*
  • Insulin / blood*
  • Male
  • Middle Aged
  • Parathyroid Glands / surgery*
  • Prospective Studies
  • Retrospective Studies


  • Blood Glucose
  • Insulin
  • Glucose