Safracins, new antitumor antibiotics. I. Producing organism, fermentation and isolation

J Antibiot (Tokyo). 1983 Oct;36(10):1279-83. doi: 10.7164/antibiotics.36.1279.

Abstract

Safracins, new antibiotics with a novel skeleton, were discovered in a culture broth of Pseudomonas sp. The producing organism has been identified as Pseudomonas fluorescens. Safracins A and B were isolated by ethyl acetate extraction and chromatography on silica gel.

MeSH terms

  • Antibiotics, Antineoplastic / isolation & purification*
  • Carbohydrate Metabolism
  • Culture Media
  • Fermentation
  • Isoquinolines / biosynthesis
  • Isoquinolines / isolation & purification
  • Kinetics
  • Nitrogen / metabolism
  • Pseudomonas fluorescens / classification
  • Pseudomonas fluorescens / growth & development*
  • Structure-Activity Relationship

Substances

  • Antibiotics, Antineoplastic
  • Culture Media
  • Isoquinolines
  • safracin A
  • safracin B
  • Nitrogen