Stability of the B vitamins in mixed parenteral nutrition solution

JPEN J Parenter Enteral Nutr. 1983 Sep-Oct;7(5):462-4. doi: 10.1177/0148607183007005462.


The effects of various light conditions such as fluorescent light, and indirect and direct sunlight on the stability of the water-soluble B vitamins in parenteral mixtures were studied. The levels of the B vitamins were determined by microbiologic assays and spectrophotometrically. Most of the B vitamins were found to be stable. However, indirect and direct sunlight destroyed 47 and 100%, respectively, of riboflavin-5-phosphate in eight hours. Direct sunlight destroyed 86% of pyridoxine HCl. There was no loss of folic acid in parenteral nutrition mixtures after storage for 7 wk. The microbiologic assays were found to be reliable to measure the levels of the B vitamins in parenteral nutrition solution.

MeSH terms

  • Bacteria / drug effects
  • Biological Assay
  • Drug Stability
  • Folic Acid / analysis
  • Light
  • Parenteral Nutrition*
  • Parenteral Nutrition, Total*
  • Vitamin B Complex / analysis*


  • Vitamin B Complex
  • Folic Acid