Long-acting contraceptive agents: analysis and purification of steroid esters

Steroids. 1983 Mar;41(3):361-7. doi: 10.1016/0039-128x(83)90107-1.

Abstract

More than 200 samples of esters of norethisterone (17 alpha-ethynyl-17 beta-hydroxyestr-4-en-3-one) and levonorgestrel (13 beta-ethyl-17 alpha-ethynyl-17 beta-hydroxygon-4-en-3 -one) have been analysed by a combination of techniques, including high performance liquid chromatography (HPLC). Compounds having a purity below the required limit (99.5%) were purified, mainly by preparative HPLC, prior to formulation and biological evaluation as long-acting progestogens.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromatography, High Pressure Liquid
  • Contraceptives, Oral / chemical synthesis*
  • Contraceptives, Oral, Combined / chemical synthesis*
  • Delayed-Action Preparations
  • Esters
  • Indicators and Reagents
  • Levonorgestrel
  • Norethindrone / analogs & derivatives*
  • Norethindrone / chemical synthesis
  • Norgestrel / chemical synthesis*
  • Stereoisomerism
  • Structure-Activity Relationship

Substances

  • Contraceptives, Oral
  • Contraceptives, Oral, Combined
  • Delayed-Action Preparations
  • Esters
  • Indicators and Reagents
  • Norgestrel
  • Levonorgestrel
  • Norethindrone