Abstract
More than 200 samples of esters of norethisterone (17 alpha-ethynyl-17 beta-hydroxyestr-4-en-3-one) and levonorgestrel (13 beta-ethyl-17 alpha-ethynyl-17 beta-hydroxygon-4-en-3 -one) have been analysed by a combination of techniques, including high performance liquid chromatography (HPLC). Compounds having a purity below the required limit (99.5%) were purified, mainly by preparative HPLC, prior to formulation and biological evaluation as long-acting progestogens.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Chromatography, High Pressure Liquid
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Contraceptives, Oral / chemical synthesis*
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Contraceptives, Oral, Combined / chemical synthesis*
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Delayed-Action Preparations
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Esters
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Indicators and Reagents
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Levonorgestrel
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Norethindrone / analogs & derivatives*
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Norethindrone / chemical synthesis
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Norgestrel / chemical synthesis*
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Contraceptives, Oral
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Contraceptives, Oral, Combined
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Delayed-Action Preparations
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Esters
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Indicators and Reagents
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Norgestrel
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Levonorgestrel
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Norethindrone