Induction and selection of drug resistant mutants of Plasmodium falciparum

Mol Biochem Parasitol. 1984 Jan;10(1):89-98. doi: 10.1016/0166-6851(84)90021-5.

Abstract

Conditions for mutagenizing Plasmodium falciparum in culture with the mutagen N-methyl-N'-nitro-N-nitrosoguanidine have been established. Parasite mutants resistant to aphidicolin, cycloheximide and sinefungin have been selected and subcloned.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenosine / analogs & derivatives
  • Adenosine / pharmacology
  • Animals
  • Aphidicolin
  • Cycloheximide / pharmacology
  • Diterpenes / pharmacology
  • Drug Resistance
  • Mutation
  • Plasmodium falciparum / genetics*
  • Selection, Genetic

Substances

  • Diterpenes
  • Aphidicolin
  • Cycloheximide
  • Adenosine
  • sinefungin