Adoptive Protection of the Mycobacterium Tuberculosis-Infected Lung. Dissociation Between Cells That Passively Transfer Protective Immunity and Those That Transfer Delayed-Type Hypersensitivity to Tuberculin

Cell Immunol. 1984 Mar;84(1):113-20. doi: 10.1016/0008-8749(84)90082-0.

Abstract

Adoptive transfer of protective immunity to an aerogenic infection with the facultative intracellular bacterium Mycobacterium tuberculosis was mediated by a population of T cells acquired in the spleen of donor mice at the height of the primary cell-mediated immune response to an immunizing infection with M. bovis bacillus Calmette-Guerin. Successful adoptive immunotherapy was ablated by prior exposure of immune donor cells to ionizing radiation or by treatment of these cells with antibody raised against the Ly-2 marker. In contrast, however, the capacity of immune donor cells to passively transfer delayed-type hypersensitivity (DTH) responses to tuberculin was unaffected by prior treatment with antibody to Ly-2, but was completely ablated by treatment by antibody to Ly-1. These results indicate, that DTH and protective anti-tuberculous immunity are dissociable phenomena, mediated by separate populations of T lymphocytes.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antigens, Ly / genetics
  • BCG Vaccine / administration & dosage
  • BCG Vaccine / immunology
  • Female
  • Hypersensitivity, Delayed / immunology*
  • Immunization, Passive*
  • Male
  • Mice
  • Mice, Inbred Strains
  • Mycobacterium tuberculosis / immunology
  • Phenotype
  • T-Lymphocytes / immunology
  • T-Lymphocytes / transplantation
  • Tuberculin / administration & dosage
  • Tuberculin / immunology*
  • Tuberculosis / immunology
  • Tuberculosis / therapy*

Substances

  • Antigens, Ly
  • BCG Vaccine
  • Tuberculin