Arthritis in rabbits induced by killed Neisseria gonorrhoeae and gonococcal lipopolysaccharide

J Rheumatol. 1984 Feb;11(1):3-8.


Intraarticular injections of viable N, gonorrhoeae, killed N. gonorrhoeae or gonococcal lipopolysaccharide (LPS) in rabbits' knees caused an acute, polymorphonuclear synovitis with abscess formation 24-72 h after the injection. At 5-7 days, a mononuclear infiltration with synovial lining cell hyperplasia developed, which in some rabbits persisted for one month. Gonococcal LPS, in amounts of 5 micrograms or greater, always caused a marked synovitis indistinguishable from that produced by viable N. gonorrhoeae. Gonococcal outer membrane protein used as a control in these experiments caused no or minimal synovitis in concentrations 50-fold higher than those used in the LPS inoculation experiments. These studies should provide a model to investigate the role of LPS in the arthritis associated with gonococcal infection.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Abscess / pathology
  • Animals
  • Arthritis, Infectious / etiology*
  • Arthritis, Infectious / pathology
  • Cell Survival
  • Cell Wall / analysis
  • Gonorrhea / pathology*
  • Humans
  • Injections, Intra-Articular
  • Knee / pathology
  • Lipopolysaccharides / toxicity*
  • Neisseria gonorrhoeae / analysis
  • Rabbits
  • Synovial Membrane / pathology
  • Synovitis / pathology
  • Time Factors


  • Lipopolysaccharides