Simultaneous measurement of renal clearance and plasma clearance of 99mTc-labelled diethylenetriaminepenta-acetate, 51Cr-labelled ethylenediaminetetra-acetate and inulin in man

Clin Sci (Lond). 1984 May;66(5):613-9. doi: 10.1042/cs0660613.


The present investigation was undertaken to study the kinetics of 99mTc-labelled diethylenetriaminepenta-acetate (DTPA) as compared with inulin and 51Cr-labelled ethylenediaminetetra-acetate (EDTA). Twenty patients with various degrees of decreased renal function were studied. The renal clearance, plasma clearance and volume of distribution of all three tracers were measured after a simultaneous single injection. The average renal clearance ratio 99mTc-DTPA to inulin was 0.97; the average renal clearance ratio 99mTc-DTPA to 51Cr-EDTA was 1.02. In all patients the plasma clearance of inulin exceeded that of 99mTc-DTPA. No difference was seen between the plasma clearance of 99mTc-DTPA and 51Cr-EDTA. The plasma clearance of all three tracers overestimated the simultaneously measured renal clearance; on average this was, for 99mTc-DTPA 5.7 ml/min, for 51Cr-EDTA 6.0 ml/min and for inulin 8.1 ml/min. The plasma clearance of 99mTc-DTPA correlated well with the renal clearance of inulin, but overestimated this by 3.5 ml/min on average. The volume of distribution of inulin was less than that of 99mTc-DTPA and 51Cr-EDTA. No difference was seen between the volume of distribution of 99mTc-DTPA and 51Cr-EDTA. It is concluded that the difference in the kinetics of 99mTc-DTPA and 51Cr-EDTA in patients with decreased renal function was small and without clinical relevance.(ABSTRACT TRUNCATED AT 250 WORDS)

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Chromium Radioisotopes
  • Edetic Acid / blood
  • Edetic Acid / metabolism*
  • Female
  • Glomerular Filtration Rate
  • Humans
  • Inulin / blood
  • Inulin / metabolism*
  • Kidney / metabolism*
  • Kidney Diseases / metabolism
  • Kinetics
  • Male
  • Metabolic Clearance Rate
  • Middle Aged
  • Pentetic Acid / blood
  • Pentetic Acid / metabolism*
  • Technetium / blood
  • Technetium / metabolism*
  • Technetium Tc 99m Pentetate


  • Chromium Radioisotopes
  • Technetium
  • Pentetic Acid
  • Inulin
  • Edetic Acid
  • Technetium Tc 99m Pentetate