Characteristic folding pattern of polytene chromosomes in Drosophila salivary gland nuclei

Nature. 1984 Mar 29-Apr 4;308(5958):414-21. doi: 10.1038/308414a0.


A computer-based system for recording and analysing light microscope images, combined with classical cytogenetic analysis, has revealed the spatial organization of the giant chromosomes of Drosophila salivary gland cells. Each polytene chromosome arm folds up in a characteristic way, contacts the nuclear surface at specific sites and is topologically isolated from all other arms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Nucleus / physiology*
  • Chromosomes / physiology*
  • Chromosomes / ultrastructure
  • DNA / genetics
  • Drosophila melanogaster / genetics*
  • Models, Genetic
  • Models, Molecular
  • Salivary Glands / physiology


  • DNA