Cerebral circulation and metabolism

J Neurosurg. 1984 May;60(5):883-908. doi: 10.3171/jns.1984.60.5.0883.


Recent developments in the field of cerebral circulation and metabolism are reviewed, with emphasis on circulatory and metabolic events that have a bearing on brain damage incurred in ischemia. The first part of the treatise reviews aspects of cerebral metabolism that provide a link to the coupling of metabolism and blood flow, notably those that lead to a perturbation of cellular energy state, ionic homeostasis, and phospholipid metabolism. In the second part, attention is focused on the derangement of energy metabolism and its effects on ion fluxes, acid-base homeostasis, and lipid metabolism. It is emphasized that gross brain damage, involving edema formation and infarction, is enhanced by tissue acidosis, and that neuronal damage, often showing a pronounced selectivity in localization, appears related to a disturbed Ca2+ homeostasis, and to Ca2+-triggered events such as lipolysis and proteolysis.

Publication types

  • Review

MeSH terms

  • Adenosine Diphosphate / metabolism
  • Adenosine Triphosphate / metabolism
  • Biological Transport, Active
  • Brain / metabolism*
  • Brain Edema / metabolism
  • Calcium / metabolism
  • Cell Membrane / metabolism
  • Cerebral Infarction / physiopathology
  • Cerebrovascular Circulation*
  • Humans
  • Ischemic Attack, Transient / metabolism
  • Ischemic Attack, Transient / physiopathology
  • Neuroglia / metabolism
  • Oxidative Phosphorylation
  • Phospholipids / metabolism
  • Potassium / metabolism
  • Prostaglandin-Endoperoxide Synthases / metabolism
  • Sodium / metabolism


  • Phospholipids
  • Adenosine Diphosphate
  • Adenosine Triphosphate
  • Sodium
  • Prostaglandin-Endoperoxide Synthases
  • Potassium
  • Calcium