Polysaccharides in fungi. XIV. Anti-inflammatory effect of the polysaccharides from the fruit bodies of several fungi

J Pharmacobiodyn. 1983 Dec;6(12):983-90. doi: 10.1248/bpb1978.6.983.

Abstract

Anti-inflammatory assays on the carrageenin-induced edema and scald-induced hyperalgesia in the hindpaw of rats were studied on polysaccharides obtained from the fruit bodies of various fungi (polysaccharide AC, BC: Tremella fuciformis;MEA, MHA, MCW-A, MCW-N: Auricularia auricula-judae; T-2-HN: Dictophora indusiata;G-A: Ganoderma japonicum). The purified polysaccharides MHA, MCW-A, G-A and T-2-HN exhibited a significant inhibitory effect on carrageenin edema. Among these polysaccharides, T-2-HN (partially O-acetylated alpha-D-mannan) also showed the marked inhibitory effect on scald hyperalgesia. We have found that T-2-HN has more potent anti-inflammatory activity than phenylbutazone in the above two inflammatory models. Since the purified polysaccharide is free from protein and lipid, it is clear that anti-inflammatory effect arises from the polysaccharide itself. The polysaccharides (T-2-HN, locust bean gun, xanthan gum) had little effect on the metabolism of arachidonic acid in canine platelets. The mechanism of the anti-inflammatory activity of the polysaccharide remains obscure.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents*
  • Arachidonic Acid
  • Arachidonic Acids / blood
  • Basidiomycota / analysis*
  • Blood Platelets / drug effects
  • Blood Platelets / metabolism
  • Carrageenan
  • Dogs
  • Edema / chemically induced
  • Edema / physiopathology
  • Pain / drug therapy
  • Polysaccharides / isolation & purification
  • Polysaccharides / pharmacology*
  • Rats
  • Rats, Inbred Strains

Substances

  • Anti-Inflammatory Agents
  • Arachidonic Acids
  • Polysaccharides
  • Arachidonic Acid
  • Carrageenan