Conservation and change in the DNA sequences coding for alcohol dehydrogenase in sibling species of Drosophila

Nature. 1984 May 31-Jun 6;309(5967):425-30. doi: 10.1038/309425a0.


The DNA sequences of the alcohol dehydrogenase (Adh) genes of four very closely related species of Drosophila show that the rates of nucleotide change vary greatly in different functional domains of this gene. A phylogeny of these species based on the Adh sequence data is consistent with that based on polytene chromosome banding patterns.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcohol Dehydrogenase
  • Alcohol Oxidoreductases / genetics*
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Biological Evolution
  • DNA / genetics
  • Drosophila / enzymology
  • Drosophila / genetics*
  • Drosophila melanogaster / enzymology
  • Drosophila melanogaster / genetics
  • Genes*
  • Phylogeny*
  • Species Specificity


  • DNA
  • Alcohol Oxidoreductases
  • Alcohol Dehydrogenase

Associated data

  • GENBANK/M19274
  • GENBANK/X00608
  • GENBANK/Z00031
  • GENBANK/Z00032
  • GENBANK/Z00033